General Information

  • ID:  hor006813
  • Uniprot ID:  B7ZS96??21-153)
  • Protein name:  Transthyretin
  • Gene name:  NA
  • Organism:  Xenopus laevis
  • Family:  Transthyretin family
  • Source:  Human
  • Expression:  Detected in plasma (at protein level). Expressed during metamorphosis in tadpole liver; but not in tadpole brain nor adult liver. Between 1.5 and 3 days of development; also expressed in the mesoderm
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus; Xenopus laevis (African clawed frog)
  • GO MF:  NA
  • GO BP:  GO:0070324 thyroid hormone binding; GO:0042802 identical protein binding; GO:0005179 hormone activity
  • GO CC:  GO:0043627 response to estrogen; GO:0070327 thyroid hormone transport

Sequence Information

  • Sequence:  PPGHASHGEADSKCPLMVKVLDAVRGIPAANLLVNVFRQTESGKWEQITSGKTTELGEIHNLTTDEQFTEGVYKIEFATKAFWGKLGLSPFHEYVDVVFTANDAGHRHYTIAVLLTPYSFSSTAIVSEPHDDL
  • Length:  133
  • Propeptide:  MASFKSFLLLALLAIVSEAAPPGHASHGEADSKCPLMVKVLDAVRGIPAANLLVNVFRQTESGKWEQITSGKTTELGEIHNLTTDEQFTEGVYKIEFATKAFWGKLGLSPFHEYVDVVFTANDAGHRHYTIAVLLTPYSFSSTAIVSEPHDDL
  • Signal peptide:  MASFKSFLLLALLAIVSEA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  A thyroid hormone binding protein that can bind triiodothyronine and thyroxine.
  • Mechanism:  A thyroid hormone binding protein that can bind triiodothyronine and thyroxine.
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    NA

Physical Information

Mass: Formula:
Absent amino acids: Common amino acids:
pI: Basic residues:
Polar residues: Hydrophobic residues:
Hydrophobicity: Boman Index:
Half-Life: Half-Life Yeast:
Half-Life E.Coli: Aliphatic Index
Instability Index: Extinction Coefficient cystines:
Absorbance 280nm:

Literature

  • PubMed ID:  NA
  • Title:  NA